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HCN2 channels in the ventral tegmental area play an important role in the pathophysiology of chronic mild stress-induced behavioral deficits.

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The most strongly associated gene set was PLCG2 (P=7.825×10−5) at a rare-variant minor allele frequency threshold of 0.05 (Supplemental Table 8). A Manhattan plot and the QQ plot for gene set–based analysis is shown in Supplemental Figures…

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The cyclin D1-CDK4 complex promotes passage through the G1 phase by inhibiting the retinoblastoma protein (pRb). Cyclin D1-CDK4 inhibits pRb through phosphorylation, allowing E2F transcription factors to transcribe genes required for entry…